Dr Dimitrios N. Gelis (MD, ORL, DDS, PhD), Aikaterini Geli (MD, Radiologist)
Grape pomace (Vinogkelin) is potent natural product with antioxidant, anti-aging and cellular protective properties. It supports cellular repair mechanisms, reduces oxidative stress, promotes cellular and gut health, and benefits stem cell function.
Grape pomace (Vinogkelin) is the byproduct of winemaking in capsules. Each capsule contains 480mg of dry powder of grape skins, seeds, and stems which are rich in bioactive compounds that may promote stem cell longevity and health.
Grape pomace (Vinogkelin) might support stem cell activity and longevity because contains natural chemicals which are potent antioxidants with anti-aging cellular protective properties and supportive cellular repair mechanisms.
Key constituents of Grape Pomace (Vinogkelin)
Polyphenols
Grape pomace of Vinogkelin contains flavonoids, resveratrol, tannins, and anthocyanins, which are potent antioxidants. Flavonoids, stilbenes, lignans, and phenolic acids, classes of polyphenols found in grape pomace (GP), have been investigated and have been proven as an important alternative source for active substances that could be used in the management of oxidative stress and inflammation[1].
Grape pomace polyphenols besides these activities, they provide many beneficial effects in ischemic heart diseases, such as the maintenance of the ventricular function as close as possible to normal, and the prevention of infarcted area extension[2].
Resveratrol
Resveratrol of the grape pomace is a phytoalexin with antioxidant anti-aging and cellular protective properties which has both chemopreventive and therapeutic effects against various ailments. Resveratrol has lately been rediscovered for a plethora of beneficial properties such as anti-cancer, anti-aging, antiviral, cardiovascular and neuroprotective effects, thereby making it one of the most sought after phytochemicals for supplementing human diet[3].
Resveratrol contributes in reducing different human cancers, including breast, cervical, uterine, blood, kidney, liver, eye, bladder, thyroid, esophageal, prostate, brain, lung, skin, gastric, colon, head and neck, bone, ovarian, and cervical[4].
Proanthocyanidins
Proanthocyanidins (PACs) are abundant in grape seeds and they are powerful antioxidants that may support cellular repair mechanisms, thus, the capacity of grape seeds extract to improve oxidative stress might mediate the inflammation process and the progress of Metabolic Syndrome (MeS)-related pathologies[5]. Grape seed proanthocyanidins (GSPs) attenuate neuronal apoptosis in ischemic stroke, which shows the potential for ischemic stroke treatment[25].
Grape seed proanthocyanidins (GSPs) have been demonstrated to exhibit anticancer effect. Meng Wang et al (2023) demonstrated that treatment with GSPs may inhibit the proliferation of pancreatic cancer cells through the modulation of miRNA expression[26].
Weibiao Xiong et al (2021) demonstrated that grape seed proanthocyanidins (GSPs) Inhibit the Development of Cutaneous Squamous Cell Carcinoma by Regulating the hsa_circ_0070934/miR-136-5p/PRAF2 Axis[27].
Vitamin E and C
Grape pomace is rich in tocopherols and tocotrienols, the compounds that collectively make up vitamin E[28] and supports oxidative stress reduction and cellular health. Vitamin E supplementation may have beneficial effects in preventing exercise-induced muscle damage and improving athletic performance in athletes[6].
Grape pomace contains vitamin C. One analysis reported approximately 26.25 mg of ascorbic acid per gram of grape pomace[29]. Another study found that grape pomace flour contained 26.25 mg of ascorbic acid per 100 grams[30].
Vitamin C supports the action of other exogenous antioxidants, mainly polyphenols. In this connection, both DNA, protein and lipids are protected against oxidation[7].
Dietary Fiber
Dietary fiber is a widely recognized nutrient for human health. Several studies proved that dietary fiber has significant implications for gastrointestinal health by regulating the gut microbiota[8].
The rapid renewal of its mucosal epithelium depends on the continuous proliferation and differentiation of intestinal stem cells (ISCs). The function and metabolism of ISCs can be controlled by a variety of dietary patterns including calorie restriction, fasting, high-fat, ketogenic, and high-sugar diets, as well as different nutrients including vitamins, amino acids, dietary fibre, and probiotics[9].
Benefits of grape pomace (Vinogkelin)
Potential Benefits of grape pomace for Stem Cell Longevity
Stem cell longevity refers to the ability of stem cells to maintain their functionality, self-renewal, and differentiation potential over time. This is crucial for tissue repair, regeneration, and overall organismal health. Mechanisms behind stem cell aging is essential for developing interventions to promote healthy aging and extend lifespan. Stem cell aging can be delayed with several biological processes which include:.
Oxidative Stress Reduction
Antioxidants in grape pomace can neutralize free radicals, which otherwise damage stem cells and reduce their regenerative potential. it is known the potential health properties of grape pomace products in the prevention of disorders associated with oxidative stress and inflammation such as endothelial dysfunction, hypertension, hyperglycemia, diabetes, obesity. Those effects are due to the bioactive compounds of grape pomace and the mechanisms concern especially modulation of antioxidant/prooxidant activity, improvement of nitric oxide bioavailability, reduction of pro-inflammatory cytokines and modulation of antioxidant/inflammatory signal pathways[10].
Anti-Inflammatory Effects
Grape pomace as a whole extract, but also different individual polyphenols that are contained in grape pomace can modulate the endogenous pathway responsible in reducing oxidative stress and chronic inflammation which is critical for maintaining a healthy stem cell niche. Among phytochemicals, polyphenols have been reported to modulate the behavior of different stem cell, either directly or indirectly, by regulating the microenvironmental niche.
In human Mesenchymal Stem Cells (MSCs), polyphenols suppress hydrogen peroxide-induced oxidative stress[11] and induce osteogenic differentiation[12]. In neural progenitors, they were found to modulate antioxidant and anti-inflammatory pathways by regulating key effectors, such as SIRT1[13]. Grape pomace, enhance the survival and proliferation of mesenchymal stem cells (MSCs) in lab settings and may improve the therapeutic effects of MSCs via enhancing their survival, self-renewal, lineage commitment, and anti-aging effects[24].
Epigenetic Modulation
Resveratrol of grape pomace may influence gene expression related to stem cell longevity and regeneration by activating pathways like sirtuins (SIRT1). Resveratrol may be the ideal candidate in the search for sirtuin-activating compounds (STACs) and could be useful in disease prevention and treatment inflammatory and neurodegenerative diseases[14].
Mitochondrial Support
Resveratrol and proanthocyanidins of grape pomace increase mitochondrial respiration and antioxidant capacity and decrease glycolytic metabolism[15] improving mitochondrial function, a key factor in stem cell energy production and survival. Resveratrol may improve the therapeutic effects of mesenchymal stromal cells (MSCs) by enhancing their survival, self-renewal, lineage commitment, and anti-aging effects. After transplantation in vivo, MSCs exert pro-angiogenic, anti-apoptotic, and antioxidative effects on host tissues and activate local quiescent stem cells to establish cellular interactions by autocrine and paracrine pathways[16].
MSCs are capable of modulating the innate immune system and influencing the functions of T and B cells, including regulatory cells, along with influencing Th1 and Th2 cell differentiation[17].
Protection against cellular senescence
Senescence is the process where cells cease to divide and function, contributing to aging and age-related diseases. Bioactive compounds in grape pomace may slow cellular aging by preventing telomere shortening and promoting DNA repair mechanisms. Telomeres are the protective caps at the ends of chromosomes which shorten with each cell division, contributing to cellular aging. Oxidative stress accelerates this shortening. Polyphenols can mitigate oxidative stress, potentially preserving telomere length[31].
Grape pomace polyphenols have demonstrated the ability to modulate cellular senescence[32]. Grape seed proanthocyanidin extract (GSPE) has been shown to ameliorate cellular senescence in retinal pigment epithelial (RPE) cells, suggesting potential therapeutic applications for degenerative retinal diseases[18].
Additionally, grape pomace polyphenols treatment significantly decreased senescence-related proteins p16 and p21, as well as the senescence-associated secretory phenotype (SASP) levels in an in-vitro aging model, indicating its potential to moderate cellular aging processes[19].
Grape pomace phenolics have been shown to counteract the formation of advanced glycation end-products (AGEs), which accumulate during aging and contribute to cellular dysfunction. Advanced glycation end products (AGEs) are generated by nonenzymatic modifications of macromolecules (proteins, lipids, and nucleic acids) by saccharides (glucose, fructose, and pentose) via Maillard reaction. The formed AGE molecules can be catabolized and cleared by glyoxalase I and II in renal proximal tubular cells. AGE-related diseases include physiological aging, neurodegenerative/neuroinflammatory diseases, diabetes mellitus and its complications, autoimmune/rheumatic inflammatory diseases, bone-degenerative diseases, and chronic renal diseases[20].
By inhibiting AGE formation, the phenolic compounds of grape pomace may help maintain cellular integrity and function over time.
Grape seed polyphenols have demonstrated potential in reducing genomic instability in a transgenic mouse model for Alzheimer’s disease, suggesting a protective effect on DNA integrity [21].
Gut Microbiome Synergy
Grape polyphenol extracts have a great influence on the recovery of gut microbiota after antibiotics and high‐fat diet treatment[22]. Fiber and polyphenols of grape pomace can enhance gut microbiota diversity, producing metabolites that positively influence stem cell activity, such as short-chain fatty acids (SCFAs).
Grape pomace may prevent thrombosis
Grape pomace phenolics may prevent thrombosis by inhibiting platelet-activating factor. Certain constituents of grape pomace such as quercetin, kaempferol and gallic acid can decrease platelet activation and aggregation. Gallic acid could slow Alzheimer’s disease by decreasing the size and formation of beta-amyloid peptides. Phenolics can decrease the expression of proto-oncogenes[23].
How to Use Grape Pomace (Vinogkelin)
Supplementation: Grape pomace (Vinogkelin) is available in capsules. Each capsule contains 480mg powder of dry seeds, skins and stems from the organic grapes cultivated dynamically in Nemea, Greece
Dosage: 1 capsule after every meal
Cautions and Considerations
Grape pomace (Vinogkelin) is generally safe if it is taken in the suggested dosage. By incorporating grape pomace (Vinogkelin) into a health-conscious diet, you can leverage its potent bioactive compounds to potentially support stem cell longevity and overall regenerative health.
Literature
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Δρ Δημήτριος Γκέλης ΜD, ORL, DDS, PhD
Δρ Δημήτριος Ν. Γκέλης (MD, ORL, DDS, PhD)
Ιατρός, Ωτορινολαρυγγολόγος, Οδοντίατρος, Διδάκτωρ της Ιατρικής Σχολής του Πανεπιστημίου Αθηνών, Ιατρικός Ερευνητής και Συγγραφέας
ΙΔΙΑΙΤΕΡΑ ΕΝΔΙΑΦΕΡΟΝΤΑ: Ιατρική Έρευνα, Συμπληρωματική Ιατρική
Διεύθυνση: ΦΛΑΜΠΟΥΡΟ ΛΟΥΤΡΑΚΙΟΥ ΚΟΡΙΝΘΙΑΣ
Τηλ: 6944280764, Email: pharmage@otenet.gr
www.gelis.gr, www.pharmagel.gr , www.orlpedia.gr , www.allergopedia.gr, d3gkelin.gr, www.vitaminb12.gr, www.zinc.gr, www.curcumin.gr
Αικατερίνη Γκέλη
Αικατερίνη ΓκέληΕχει ιδιαίτερο ενδιαφέρον στη διαγνωστική με υπερήχους, κλασσική ακτινολογία παίδων και ενηλίκων, γναθοπροσωπική ακτινολογία, περιβαλλοντική ιατρική, ιατρική διατροφολογία, συμπληρωματική ιατρική.
Την ευθύνη της διάγνωσης, θεραπείας και πρόληψης των ασθενειών τις έχει μόνον ο θεράπων ιατρός του κάθε ασθενούς, αφού πρώτα κάνει προσεκτικά ακριβή διάγνωση.
Γιαυτό συνιστάται η αποφυγή της αυθαίρετης εφαρμογής ιατρικών πληροφοριών από μη ιατρούς. Τα συμπληρώματα διατροφής δεν είναι φάρμακα, αλλά μπορεί να χορηγούνται συμπληρωματικά, χωρίς να παραιτούνται οι ασθενείς από τις αποδεκτές υπό της ιατρικής επιστήμης θεραπείες ή θεραπευτικές τεχνικές και μεθόδους, που γίνονται, όταν χρειάζονται, υπό ιατρική καθοδήγηση, παρακολούθηση και ευθύνη. Οι παρατιθέμενες διαφημίσεις εξυπηρετούν της δαπάνες συντήρησης της παρούσας ιστοσελίδας Το παρόν άρθρο προστατεύεται από το Νόμο 2121/1993 και 4481/2017 για την πνευματική ιδιοκτησία. Η ολική ή μερική αντιγραφή του παρόντος επιστημονικού άρθρου χωρίς τη γραπτή έγκριση του Δρ Δημητρίου Ν. Γκέλη θεωρείται κλοπή πνευματικής ιδιοκτησίας και διώκεται βάσει της νομοθεσίας.